2 comments

  • brisko389

    I would attribute its greater solubility to the fact that it contains more hydrophilic groups: the COOH and 3 OH groups. These groups are polar and can form H bonds with water molecules making the substance soluble in water. By contrast, cholesterol has only 1 OH group and will make it less soluble.

    The distribution/locationof the polar groups in the molecule of cholic acid might also be significant in enhancing its solubility in water.

  • moneymonty

    water is a polar molecule, and like dissolves like, therefore, the more polar of the two moleucles will have the higher solubility.
    Cholesterol is basically composed of H and C with a hydroxy group, and cholic acid has multiple hydroxy groups and a carboxylic acid group making it more polar and thus more soluble.

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